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Gyógygombák : Gyógygomba és flavonoid kivonatok rövid ismertetése hivatkzások

Gyógygomba és flavonoid kivonatok rövid ismertetése hivatkzások

Egyes természetes növényi illetve gomba eredetű hatóanyagokat: speciális, egyedi polysaccharidokat, néhány országokban (mint például Japán) már tumorellenes gyógyszerként is engedélyeztek. A japán gondolkodásmóddal is összefüggésben lehet, hogy ott rendkívül alacsony a rákbetegség következtében elhalálozók aránya. A speciális polysaccharidok hatásukat tekintve többek között képesek elvágni a tumorsejtek vérellátását és aktiválni az NK és falósejtek tumorölő funkcióit, növelni az inzulin- érzékenységet és csökkenteni az inzulinszintet elősegítve ezzel a betegek gyógyulását. Az egyik legeredményesebb polysaccharida, a Patkónyelv-gomba kivonata képes volt számos előrehaladott rákbetegnél is a szervezet öngyógyító mechanizmusát beindítani, ami nagy feltűnést keltett a rákkutatók körében.


 

Hivatkozások:

[1] Fachet József: Immunválaszok genetikai szabályozása és modulációja polysaccharidákkal: Tumor immunotherápiás és immun-biotechnológiai vonatkozások; Debrecen, 1993. MTA, Doktori Értekezés Tézisei

[2] lásd uo.

[3] Fachet et al.: Modulation of immune responses and defense against tumor by a polymannan-polyglycan polysaccharide; Mannozym; Int.J.Immunopharmacol. 1980; 2, 185.

[4] Lapis, K. et al.: Experimental metastasis inhibition by pretreatment of the host;  In: Arch Geschwulstforsch., 1990; 60(2): 97-102.

[5] Ladanyi, A., Timar, J., Lapis, K.: Effect of lentinan on macrophage cytotoxicity against metastatic tumor cells; In: Cancer Immunol Immunother, 1993; 36(2): 123-6.

[6] Zákány, J. et al.: Effect of lentinan on tumor growth in murine allogeneic and syngeneic hosts; Int. J. Cancer; 1980, 25, 371-376.

[7] Suga et al.: Effect of lentinan against allogeneic, syngeneic and autologous primary tumours and its prophylactic effect on chemical carcinogenesis; In:  Manipulation of Host defence Mechanism III. Eds. Aoki et al.: Excepta Medica; 1985, 116-128.

[8] Fachet,J: Effects of mannozym, a polyglucan-polymannan, on different immune responses and resistanse to tumor; In: Adv. in Immunopharmacology. Ed. By Hadden et al. Pergamon Press, 1981. 483.

[9] Fachet, J: A szervezet endokrin és immunvédekező rendszerei; Orvostudomány, 1982, 33, 261-274.

[10] Zákány, J. et al: Mechanism of the AIPh.MCS1 tumor graft rejection in syngeneic mice; Gann. 1983, 74, 712-722

[11] Suga et al.: Effect of lentinan against allogeneic, syngeneic and autologous primary tumours and its prophylactic effect on chemical carcinogenesis; In:  Manipulation of Host defence Mechanism III. Eds. Aoki at al.: Excepta Medica; 1985, 116-128.

[12] Fachet József: Immunválaszok genetikai szabályozása és modulációja polysaccharidákkal: Tumor immunotherápiás és immun-biotechnológiai vonatkozások; Debrecen, 1993. MTA, Doktori Értekezés Tézisei

[13] uo.

[14] Sipka, S. et al.: Effect of lentinan on  the chemiluminescence produced by human neutrophils and the murine macrophage cell line C4MΦ; Int.J. Immunopharmacol., 1985,7, 747-751.

[15] Ábel Gy.et al: Effect of lentinan and mannan on phagocytosis of fluorescent latex microbeads by mouse peritoneal macrophages: A flow cytometric study; Int.J.Immunopharmacology; 1989, 11, 615-621.

[16] Ábel Gy.et al.: Effect of lentinan on pinocytosis in mouse peritoneal macrophages and the murine macrophage cell line C4MI in vitro; Int.J.Immunopharmac,1986, 8, 919-924.

[17] Kerékgyártó, Cs.et al.: Strain differences in  the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan; Int.J.Immunopharmacology, 1996, 18, 347-353.

[18] Fachet,J.et al.: Potentiation of non-specific host defense by polysaccharides like lentinan: possible mechanism; Int.J.Immunotherapy, 1989, 5, 167-176.

[19] Fachet, J. et al: Polysaccharidák immunmodulációs hatásai , daganatellenes alkalmazása és hatásmechanizmusa; TAIM Nemzetközi Alapítvány IV. Tudományos Konferenciája, 1997, 102-113.

[20] Fachet,J.et al.: Potentiation of non-specific host defense by polysaccharides like lentinan: possible mechanism; Int.J.Immunotherapy, 1989, 5, 167-176.

[21] Fachet, J. et al: Polysaccharidák immunmodulációs hatásai , daganatellenes alkalmazása és hatásmechanizmusa; TAIM Nemzetközi Alapítvány IV. Tudományos Konferenciája, 1997, 102-113.

[22] Fachet et al.: Effect of lentinan on different types of immune responses including anaphylactic shock; In: „Host defense mechanisms against cancer”, Proc. of  7th Symp. on host defense mechanism against cancer, Hakone, Japan, 1985. nov. 8-10. Excerpta Medica; 1986, 183-194.

[23] Zákány, J. et al.: Effect of lentinan on the production of migration inhibitory factor (MIF) induced by syngeneic tumor in mice; Int. J. Cancer, 1980, 26, 783-788.

[24] Kerékgyártó, Cs.et al.: Strain differences in  the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan; Int.J.Immunopharmacology, 1996, 18, 347-353.

[25] Fachet,J.et al.: Potentiation of non-specific host defense by polysaccharides like lentinan: possible mechanism; Int.J.Immunotherapy, 1989, 5, 167-176.

[26] Fachet, J. et al: Polysaccharidák immunmodulációs hatásai , daganatellenes alkalmazása és hatásmechanizmusa; TAIM Nemzetközi Alapítvány IV. Tudományos Konferenciája, 1997, 102-113.

[27] Fachet József: Immunválaszok genetikai szabályozása és modulációja polysaccharidákkal: Tumor immunotherápiás és immun-biotechnológiai vonatkozások; Debrecen, 1993. MTA, Doktori Értekezés Tézisei

[28] uo.

[29] Kerékgyártó, Cs.et al.: Strain differences in  the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan; Int.J.Immunopharmacology, 1996, 18, 347-353.

[30] Fachet,J.et al.: Potentiation of non-specific host defence by polysaccharides like lentinan: possible mechanism; Int.J.Immunotherapy, 1989, 5, 167-176.

[31] Fachet, J. et al: Polysaccharidák immunmodulációs hatásai , daganatellenes alkalmazása és hatásmechanizmusa; TAIM Nemzetközi Alapítvány IV. Tudományos Konferenciája, 1997, 102-113.

[32] Kodama, N.et al.: Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice; In:J Med Food, 2004, 7(2):141-5.

[33] el-Mekkawy, S. et al.: Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum; In:Phytochemistry, 1998, 49(6):1651-7.

[34] Min, BS. et al.: Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease; In: Chem Pharm Bull (Tokyo), 1998, 46(10):1607-12.

[35] Szakirodalmi adatokat a tumorellenes hatás tekintetében lásd később a részletes összefoglalókban.

[36] Bernardshaw, S. et al.: An extract f the mushroom Agaricus blazei Murill administered orally protects against systemic Streptococcus pneumoniae infection in mice; In: Scand J Immunol. 2005, 62(4): 393-8.

[37] Eo, SK. et al.: Antiviral activities of various water and methanol soluble substances isolated from Ganoderma lucidum; In: J. Ethnopharmacol. 1999, 68(1-3): 129-136.

[38] Horio, H. et al.: Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats; In: J Nutr Sci Vitaminol (Tokyo), 2001, 47(1): 57-63.

[39] Kubo, K. et al.: Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake).I.; In: Biol Pharm Bull, 1994, 17(8):1106-10.

[40] Kim, YW. et al.: Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei; In: Biotechnol Lett., 2005, 27(7): 483-7.

[41] Hikino, H. et al.: Mechanism of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies; In: Panta Med., 1989, 55(5):423-8.

[42] Zhang, H. et al.: Hypoglycemic effect of Ganoderma lucidum polysaccharides; In: Acta Pharmacol Sin, 2004, 25(2): 191-195.

[43] Zhang, HN. et al.: In vitro and in vivo protective effect of Ganoderma lucidum polyaccharides on alloxan-induced pancreatic islets damage; In: Life Sci. 2003, 73(18):2307-19.

[44] Lee, SY. et al.: Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action; In: Chem Pharm Bull (Tokyo).,1990, 38(5): 1359-64.

[45] Kabir, Y. et al.: Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats; In: J Nutr Sci Vitaminol (Tokyo), 1987, 33(5): 341-6.

[46] Tasaka, K. et al.: Anti-allergic constituents in the culture medium of Ganoderma lucidum. (II). The inhibitory effect of cyclooctasulfur on histamine release; In: Agent Actions, 1988, 23(3-4):157-60.

[47] Berger, A.et al.: Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs; In: Lipids Health Dis., 2004,18;3:2.

[48] Kim, YW. et al.: Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei; In: Biotechnol Lett., 2005, 27(7): 483-7.

[49] Komoda, Y. et al.: Ganoderic acid and its derivatives as cholesterol synthesis inhibitors; In: Chem Pharm Bull (Tokyo)., 1989, 37(2): 531-3.

[50] Fukushima, M. et al.: Cholesterol-Lowering Effects of Maitake…In: Exp Biol Med., 2001, 226(8): 758-765.

[51] Hajjaj, H. et al.: Effect of 26-Oxygenosterols from Ganoderma lucidum and Their Activity as Cholesterol Synthesis Inhibitors; In: Applied and Enviromental Microbiology, 2005, July, p. 3653-3658.

[52] Kubo, K. et al.: Anti-hyperliposis effect of maitake fruit body (Grifola frondosa).I.; In: Biol Pharm Bull., 1997, 20(7): 781-5.

[53] Kabir, Y. et al.: Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats; In: J Nutr Sci Vitaminol (Tokyo), 1987, 33(5): 341-6.

[54] Ren, LK. et al.: Anti-atherosclerotic properties of higher mushrooms (a clinico-experimental investigation); In: Vopr Pitan, 1989,(1):16-9.

[55] Kim, YW. et al.: Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei; In: Biotechnol Lett., 2005, 27(7): 483-7.

[56] Tao, J. et al.: Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation; In: J Tongji Med Univ, 1990, 10(4): 240-3.

[57] Lin, H. et al.: Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro; In: Int Immunopharmacol., 2004, 4(1): 91-9.

[58] Zhao, H. et al.: Polysaccharide Extract Isolated From Ganoderma lucidum Protects Rat Cerebral Cortical Neurons From Hypoxia/Reoxygenation Injury; In: J. Pharmacol Sci. 2004, 95, 294-288.

[59] Nishina, A. et al.: Lysophosphatidy lethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAP kinase; In: J Lipid Res. 2006, Apr. 13.

[60] uo.

[61] Zhu, WW. et al.: Effect of the oil from ganoderma lucidum spores on pathological changes in the substantia nigra and behaviors of MPTP-treated mice; In: Di Yi Jun Da Xue Xue Bao, 2005, 25(6):667-71.

[62] Tang, W. et al: A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia; In: J. Med Food, 2005, 8(1):53-8.

[63] Shieh, YH. et al.: Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice; In: Am J Chin Med., 2001, 29 (3-4): 501-7.

[64] Li, Y. et al.: Anti-hepatitis Activities in the Broth of Ganoderma lucidum…; In:Am J Chin Med., 2006, 34(2): 341-9.

[65] Yang, XJ. et al.: In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury; In: World J Gastroenterol., 2006, 12(9):1379-85.

[66] Zhang, GL. et al.: Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG- induced immune liver injury in mice; In: World J Gastroenterol., 2002, 8(4): 728-33.

[67] Lin, JM. et al.: Radical scavenger and antihepatotoxic activity of Ganoderma…; In: J Ethnopharmacol. 1995, 47(1): 33-41.

[68] Lin, WC. et al.: Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats; In: Gastroenterol., 2006, 12(2): 265-270.

[69] Kodama, N. et al: Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice. In:J Med Food 2004 Summer;7(2):141-5.

[70] Kodama, N. et al.: Effects of D-Fraction…In: Biol Pharm Bull 2002 Dec;25(12):1647-50

[71] Kodama, N. et al.:Enhancement of cytotoxicity of NK cells by D-Fraction…In:Oncol Rep 2005 Mar;13(3):497-502

[72] Kodama, N. et al.:Effect of Maitake (Grifola frondosa) D-Fraction on activation of NK cells in cancer patients In:J Med Food 2003 Winter;6(4):371-7.

[73] Jiang, J. et al..: Ganoderma lucidum suppresses growth of breast cancer cells, In:Nutr Cancer 2004;49(2):209-216.

[74] Jiang, J. et al.: Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3, In: Int J Oncol 2004 May;14(5):1093-9.

[75] Lu, QY.et al.: Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro, In: Cancer Lett 2004 Dec 8;216(1):9-20.

[76] Stanley, G. et al.: Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells; In:Biochem Biophys Res Commun, 2005, 330(1):46-52.

[77] Muller, CI. et al.: Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells; In: Leuk Res. 2006 jan. 16.

[78] Cao, QZ. et al.: Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell; In: Life Sci. 2006, 78(13): 1457-63.

[79] Kimura, Y. et al.: Antitumor and antimetastatic effects on liver of triterpenoid  fractions of Ganoderma lucidum:… In:Anticancer Res 2002 Nov-Dec;22(6A):3309-18.

[80] Lu, H .et al.: A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia suppresses azoxymethane –induction of colon cancers in male  F344 rats, In:Oncol Rep 2003 Mar-Apr;10(2):375-9

[81] Gao, Y.et al.: Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients, In: Immunol Invest 2003 Aug;32(3):201-15

[82] Nakajima, A. et al.: Effect of hot water extract from Agaricus blazei Murill on antibody-producing cells in mice, In: Int Immunopharmacol 2002 Jul;2(8):1205-11.

[83] Lee YL: Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model, In: Exp Anim 2003 Oct;52(5):371-5.

[84] Kaneno, R. et al: Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity…In: Food Chem Toxicol 2004 Jun;42(6):909-16.

[85] Kobayashi, H. et al.: Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated  metastasis in mouse model; In: J Cancer Res Clin Oncol., 2005, 131(8): 527-38.

[86] Kubo N. et al.: Protective effects of a water-soluble extract…In: Int J Mol Med 2005 Mar;15(3):401-6.

[87] Ahn, WS. et al.: Natural killer cell activity and quality of life were improved by consumption of a mushroom extract…In:Int J Gynecol Cancer 2004 Jul-Aug;14(4):589-94.

[88] Lelley, J.: Die Heilkraft der Pilze, 2003, Ulm.

[89] Ley, M. Beth: Agaricus Blazei Murill, 2001, BL Publications.

[90] Hwang, J.et al.: Soy and alfalfa phytoestrogen extracts become potent low-density lipoprotein antioxidants in the presence of acerola cherry extract; In: J Agric Food Chem. 2001, 49(1):308-14.

[91] Nagamine,I.:et al.: Effect of acerola cherry extract on cell proliferation and activation of ras signal pathway at the promotion stage of lung tumorigenesis in mice; In: J Nutr Sci Vitaminol (Tokyo), 2002, 48(1):69-72.

[92] Motohashi, N et al.: Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions; In: Phytother Res. 2004, 18(3):212-23.

 

 

     

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